- Catalog number
- A07060
- Size / count
- 100 µg
- Dry ice
- No
- Hazardous
- No
- Discontinued
- No
- Background
- IL-29 (Interleukin-29) is a secreted cytokine with immunomodulatory activity. It may play a role in antiviral immunity. It up-regulates MHC class I antigen expression. IL-29 is a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Its induction is by viral infections or double stranded RNA. Anti-IL-29 antibody is ideal for investigators involved in Immunology research.
- Synonyms
- IL-29, Interferon lambda-1, IFN-lambda-1, Interferon lambda-1, Cytokine Zcyto21, Interleukin-29, IL-29, IFNL1, IL29, ZCYTO21
- Gene Name
- IFNL1
- UniProt
- Q8IU54
- Host
- Rabbit
- Reactivity
- Human
- Immunogen
- This IgG fraction antibody was prepared from rabbit antiserum after repeated immunizations with mature length recombinant human IL-29 protein produced in E.coli.
- Clonality
- Polyclonal
- Applications
- ELISA, WB
- Field of Research
- Cytokines, Immunology, Innate Immunity, Interleukins
- Purification
- Anti-IL-29 is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer stated above. This antibody is specific for human IL-29 protein. A BLAST analysis was used to suggest cross-reactivity with IL-29 from human sources based on 100% homology with the immunizing sequence. Based on high to 100% homology, there is a chance of cross-reactivity to IL-29 from a wide variety of animals. Cross-reactivity with IL-29 from other sources has not been determined.
- Concentration
- 1.0 mg/mL by UV absorbance at 280 nm
- Form
- Lyophilized
- Reconstitution
- Restore with deionized water (or equivalent) for reconstitution volume of 100 μL
- Function
- Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
- Storage Conditions
- Store anti-IL-29 antibody at 4°C prior to restoration. For extended storage aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is six (6) months from date of opening. (Ship at ambient temperature.)
- Observed Molecular Weight
- 21898 MW
- Gene Name Synonym
- Interferon lambda-1
- Subcellular Location
- Secreted.
- Isotype
- IgG
- Contents
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
