Anti-Collectin-12 COLEC12 Antibody

About this product

Boster Bio Anti-Collectin-12 COLEC12 Antibody catalog # A07213. Tested in WB applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

A07213

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Collectin-12; Collectin placenta protein 1; CL-P1; hCL-P1; Nurse cell scavenger receptor 2; Scavenger receptor class A member 4; Scavenger receptor with C-type lectin; COLEC12; CLP1, NSR2, SCARA4, SRCL

Gene Name

COLEC12

UniProt

Q5KU26

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Recombinant fusion protein of human COLEC12 (NP_569057.1) .

Clonality

Polyclonal

Tissue Specificity

Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level) . Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient.

Applications

WB

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR) . May also play a role in the clearance of amyloid-beta in Alzheimer disease.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

81515 MW

Applications Notes

WB: 1:500-1:2000

Gene Name Synonym

Collectin-12

Subcellular Location

Membrane

Protein Name

Collectin-12

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2