Anti-Protein Hook homolog 3 HOOK3 Antibody

About this product

Boster Bio Anti-Protein Hook homolog 3 HOOK3 Antibody (Catalog # A07701) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A07701

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The HOOK proteins (HOOK1, HOOK2 and HOOK3) comprise a family of cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules mediating the spatial organization of diverse membrane-trafficking systems; their more divergent C-terminal domains mediate binding to organelles (1,2) . HOOK3 exists as a homodimer and participates in defining the architecture and localization of the Golgi complex through its central coiled-coil domain (3) . HOOK3 may regulate clearance of endocytosed receptors such as MSR1 (3,4) .

Synonyms

Hook microtubule-tethering protein 3, HK3, h-hook3, hHK3, FLJ31058, Protein Hook homolog 3

Gene Name

HOOK3

UniProt

Q86VS8

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

HOOK3 antibody is human, mouse and rat reactive. HOOK3 antibody is predicted to not cross-react with HOOK1 and HOOK2.

Immunogen

HOOK3 antibody was raised against a 19 amino acid peptide from near the amino terminus of human HOOK3. The immunogen is located within amino acids 210 - 260 of HOOK3.

Clonality

Polyclonal

Applications

ELISA, WB, IHC-P, IF

Field of Research

Homeostasis

Purification

HOOK3 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity) . Component of the FTS/Hook/FHIP complex (FHF complex) . The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) . May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non- processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494) .

Storage Conditions

HOOK3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Observed Molecular Weight

83126 MW

Gene Name Synonym

Hook microtubule-tethering protein 3

Subcellular Location

Cytoplasm, cytoskeleton

Protein Name

Hook microtubule-tethering protein 3

Isotype

IgG

Contents

HOOK3 Antibody is supplied in PBS containing 0.02% sodium azide.