Anti-MYT1L Antibody

About this product

Boster Bio Anti-MYT1L Antibody (Catalog # A07880) . Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A07880

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The myelin transcription factor 1 family, to which the myelin transcription factor 1-like protein (MYT1L) belongs, is expressed primarily in the developing central nervous system and recruits histone deacetylase (HDAC) to regulate neural transcription. Both MYT1L and the related protein MYT1 interact with SIN3B, a protein that mediates transcriptional repression by binding to HDACs, suggesting that the MYT1 family favor the silencing of genes during neural development. Recent studies suggest that polymorphisms of MYT1L may be associated with schizophrenia.

Synonyms

NZF1, ZC2HC4B, KIAA1106, Myelin transcription factor 1-like protein, MyT1-L

Gene Name

MYT1L

UniProt

Q9UL68

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

At least three isoforms are known to exist. This antibody will only recognize the two longest isoforms.

Immunogen

Rabbit polyclonal MYT1L antibody was raised against an 18 amino acid peptide near the carboxy terminus of human MYT1L. The immunogen is located within the last 50 amino acids of MYT1L.

Clonality

Polyclonal

Applications

ELISA, WB, IF

Field of Research

Neuroscience

Purification

MYT1L Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non- neuronal genes during neuron differentiation. In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs. Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Directly binds the 5'-AAGTT- 3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B. The 5'-AAGTT-3' core motif is absent from the promoter of neural genes.

Storage Conditions

MYT1L antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

133043 MW

Gene Name Synonym

Myelin transcription factor 1-like

Subcellular Location

Nucleus

Protein Name

Myelin transcription factor 1-like

Isotype

IgG

Contents

MYT1L Antibody is supplied in PBS containing 0.02% sodium azide.