Anti-ECSIT Antibody

About this product

Boster Bio Anti-ECSIT Antibody (Catalog # A07966) . Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

A07966

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Activation of NF-κB as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses. Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88 to kinases such as IRAK and other intermediates such as TNF receptor associated factor (TRAF) -6. ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) was initially identified as a cytoplasmic protein interacting specifically with TNF receptor associated factor (TRAF) -6 in the TLR pathway. Recently however, ECSIT has also been shown to be required for bone morphogenetic protein (Bmp) signaling and mesoderm formation during mouse embryogenesis, indicating the possibility of cross-talk between the TLR/IL-B and Bmp signaling pathways.

Synonyms

SITPEC, Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial, Protein SITPEC

Gene Name

ECSIT

UniProt

Q9BQ95

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

ECSIT antibody was raised against a peptide corresponding to 14 amino acids near the C-terminus of human ECSIT. The immunogen is located within amino acids 290 - 340 of ECSIT.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in thyroid, pancreas, spinal cord, lymph node, trachea, adrenal gland, bone marrow and pancreas. Detected at low levels in heart, breast, placenta, brain, liver, kidney, stomach and lung.

Applications

ELISA, WB, IHC-P

Field of Research

Neuroscience

Purification

ECSIT Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity) . .

Storage Conditions

ECSIT antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

49148 MW

Gene Name Synonym

ECSIT homolog (Drosophila)

Subcellular Location

Cytoplasm

Protein Name

ECSIT homolog (Drosophila)

Isotype

IgG

Contents

ECSIT Antibody is supplied in PBS containing 0.02% sodium azide.