Anti-XEDAR EDA2R Antibody

About this product

Boster Bio Anti-XEDAR EDA2R Antibody (Catalog # A08575) . Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human.

Specifications

Catalog number

A08575

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

X-linked ectodysplasin-A2 receptor (XEDAR) is a recently isolated member of the tumor necrosis factor receptor family that is highly expressed during embryonic development and binds to ectodysplatin-A2 (EDA-A2) . Two predominantly expressed isoforms, XEDAR-s and XEDAR-L, differ by only a 21-amino region at the juxtamembrane region of the cytoplasmic domain. Neither isoform possesses a death domain and both have been shown to act mainly through TRAF3 and TRAF6 to activate the NF-κB and JNK pathways. Cells transfected with XEDAR and treated with EDA-A2 cause the assembly of a secondary complex containing FADD, caspase-8 and caspase-10, leading to the activation caspase-8 and caspase-3, and finally apoptosis. The EDA-A2-induced apoptosis is dependent on caspase-9 activation, as various pharmacological and genetic inhibitors of caspase-8 blocked apoptosis following EDA-A2 treatment.

Synonyms

XEDAR, EDAA2R, EDA-A2R, TNFRSF27, XEDAR, UNQ2448/PRO5727/PRO34080, Tumor necrosis factor receptor superfamily member 27, X-linked ectodysplasin-A2 receptor, EDA-A2 receptor

Gene Name

EDA2R

UniProt

Q9HAV5

Host

Rabbit

Reactivity

Human

Immunogen

XEDAR antibody was raised against recombinant human XEDAR.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in B-cells, monocytes and tonsil.

Applications

ELISA, WB, IHC-P

Field of Research

Signal Transduction

Purification

XEDAR Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.

Storage Conditions

XEDAR antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

32759 MW

Gene Name Synonym

Ectodysplasin A2 receptor

Subcellular Location

Membrane; Single-pass type III membrane protein.

Protein Name

Ectodysplasin A2 receptor

Isotype

IgG

Contents

XEDAR Antibody is supplied in PBS containing 0.02% sodium azide.