Anti-UBQLN4/A1Up Antibody

About this product

Boster Bio Anti-UBQLN4/A1Up Antibody (Catalog# A08887) . Tested in WB, IHC, ICC, IF, ELISA applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

A08887

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

UBQLN4; C1orf6; CIP75; UBIN; Ubiquilin-4; Ataxin-1 interacting ubiquitin-like protein; A1Up; Ataxin-1 ubiquitin-like-interacting protein A1U; Connexin43-interacting protein of 75 kDa; CIP75

Gene Name

UBQLN4

UniProt

Q9NRR5

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

A peptide derived from human UBQLN4. Immunogen sequence location: 201 - 250

Clonality

Polyclonal

Tissue Specificity

Highly expressed in pancreas, kidney, skeletal muscle, heart and throughout the brain, and at lower levels in placenta, lung and liver.

Applications

WB, IHC, ICC, IF, ELISA

Field of Research

Cell Biology, Proteasome / Ubiquitin, Proteolysis/Ubiquitin, Ub-Like Proteins

Purification

The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.

Concentration

0.5-1mg/mL, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Plays a role in the regulation of protein degradation via the ubiquitin-proteasome system (UPS) . Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (Ref. 6) . Plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity) . Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery. Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205) .

Storage Conditions

Store at -20°C for one year. For short-term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

63853 MW

Gene Name Synonym

Ubiquilin-4

Subcellular Location

Nucleus. Cytoplasm. Endoplasmic reticulum. Cytoplasm, perinuclear region. Cytoplasmic vesicle, autophagosome. Colocalizes with the proteasome, both in nucleus and cytoplasm.

Isotype

Rabbit IgG

Contents

PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.