Anti-TOM70 TOMM70 Antibody

About this product

Boster Bio Anti-TOM70 TOMM70 Antibody (Catalog # A09172) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A09172

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The translocase of outer mitochondrial membrane (TOM) complex is a multisubunit complex involved in the recognition, unfolding, and translocation of preproteins into the mitochondria. TOM70, an important member of the TOM complex, contains a tetratricopeptide repeat domain similar to those found in cytosolic chaperones such as Hsp90 and Hsc70 and provides a docking site for these proteins. This interaction is thought to be a critical first step in the TOM70-dependent mitochondrial import, followed by contact between the preprotein and TOM70. After targeting to TOM70, preproteins are translocated through the outer membrane via the TOM40 import pore complex. The precise mechanism of how preproteins progress from TOM70 to TOM40 to full translocation is still unclear.

Synonyms

KIAA0719, TOM70, Mitochondrial import receptor subunit TOM70, Mitochondrial precursor proteins import receptor

Gene Name

TOMM70A

UniProt

O94826

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

At least two isoforms of TOM70 are known to exist; this antibody will only detect the larger isoform.

Immunogen

Anti-TOM70 antibody was raised against a peptide corresponding to 17 amino acids near the amino terminus of human TOM70. The immunogen is located within amino acids 50-100 of TOM70.

Clonality

Polyclonal

Tissue Specificity

Ubiquitous. Highly expressed in liver, kidney and muscle. Expressed at intermediate level in brain, heart, colon, thymus, kidney, small intestine, placenta, lung, leukocytes and spleen.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Homeostasis

Purification

TOM70 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Receptor that accelerates the import of all mitochondrial precursor proteins. .

Storage Conditions

TOM70 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

67455 MW

Gene Name Synonym

Translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)

Subcellular Location

Mitochondrion outer membrane ; Single-pass membrane protein .

Protein Name

Translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)

Isotype

IgG

Contents

TOM70 Antibody is supplied in PBS containing 0.02% sodium azide.