Anti-Transmembrane protein 59 TMEM59 Antibody

About this product

Boster Bio Anti-Transmembrane protein 59 TMEM59 Antibody (Catalog # A09364) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.

Specifications

Catalog number

A09364

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59, a Golgi-localized protein, modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. It inhibits APP transport and shedding.

Synonyms

C1orf8, HSPC001, C1orf8, UNQ169/PRO195, Transmembrane protein 59, Liver membrane-bound protein

Gene Name

TMEM59

UniProt

Q9BXS4

Host

Rabbit

Reactivity

Human

Immunogen

TMEM59 antibody was raised against a 16 amino acid synthetic peptide near amino terminus of human TMEM59. The immunogen is located within amino acids 80 - 130 of TMEM59.

Clonality

Polyclonal

Applications

ELISA, WB, IHC-P, IF

Field of Research

Neuroscience

Purification

TMEM59 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C) . Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy (PubMed:27273576, PubMed:23376921) . Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP (PubMed:20427278) . Inhibits APP transport to the cell surface and further shedding (PubMed:20427278) .

Storage Conditions

TMEM59 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

36223 MW

Gene Name Synonym

Transmembrane protein 59

Subcellular Location

Late endosome membrane

Prediction Reactivity

Pig, Bovine, Mouse

Protein Name

Transmembrane protein 59

Isotype

IgG

Contents

TMEM59 Antibody is supplied in PBS containing 0.02% sodium azide.