Anti-SCARA5 Antibody

About this product

Boster Bio Anti-SCARA5 Antibody (Catalog # A09571) . Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human.

Specifications

Catalog number

A09571

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Scavenger receptor class A member 5 (SCARA5), also known as TESR, is part of the scavenger receptor superfamily, which is composed of many members with diverse structures, expression patterns, and functions. SCARA5 is a cell-surface receptor that contains the collagen-like domain and N-terminal scavenger receptor cysteine rich domain typical of the class A scavenger receptor subfamily. Unlike other class A receptors, SCARA5 does not endocytose acetylated or oxidized low density lipoprotein. Instead, SCARA5 binds serum ferritin and mediates its endocytosis from the cell surface, indicating SCARA5 may play a role in non-transferrin iron delivery.

Synonyms

Tesr, NET33, Scavenger receptor class A member 5, Scavenger receptor hlg

Gene Name

SCARA5

UniProt

Q6ZMJ2

Host

Rabbit

Reactivity

Human

Cross Reactivity

At least four isoforms of SCARA5 are known to exist; this antibody will detect all four isoforms.

Immunogen

SCARA5 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human SCARA5. The immunogen is located within amino acids 350 - 400 of SCARA5.

Clonality

Polyclonal

Applications

ELISA, WB, ICC, IF

Field of Research

Homeostasis

Purification

SCARA5 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Ferritin receptor that mediates non-transferrin- dependent delivery of iron. Mediates cellular uptake of ferritin- bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type- specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1) .

Storage Conditions

SCARA5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

53994 MW

Gene Name Synonym

Scavenger receptor class A, member 5 (putative)

Subcellular Location

Cell membrane

Prediction Reactivity

Bovine, Mouse, Chicken, Rat

Protein Name

Scavenger receptor class A, member 5 (putative)

Isotype

IgG

Contents

SCARA5 Antibody is supplied in PBS containing 0.02% sodium azide.