Anti-KHDRBS2 Antibody

About this product

Boster Bio Anti-KHDRBS2 Antibody catalog # A09665. Tested in WB, IHC applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

A09665

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

KH domain-containing, RNA-binding, signal transduction-associated protein 2; Sam68-like mammalian protein 1; SLM-1; hSLM-1; KHDRBS2; SLM1

Gene Name

KHDRBS2

UniProt

Q5VWX1

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

A synthetic peptide of human KHDRBS2 (NP_689901.2) .

Clonality

Polyclonal

Tissue Specificity

Highly expressed in brain, lung, kidney and small intestine. Weakly expressed in placenta, liver, spleen, thymus, ovary and colon.

Applications

WB, IHC

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly (A) and poly (U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity) . Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergystically with SAM68 in exon skipping. In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. May function as an adapter protein for Src kinases during mitosis.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

38927 MW

Gene Name Synonym

KH domain-containing, RNA-binding, signal transduction-associated protein 2

Subcellular Location

Nucleus

Protein Name

KH domain-containing, RNA-binding, signal transduction-associated protein 2

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2