Anti-Acetyl-Histone H2B (K126) HIST1H2BA Antibody

About this product

Boster Bio Anti-Acetyl-Histone H2B (K126) HIST1H2BA Antibody catalog # A09942. Tested in WB, ELISA applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A09942

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Histone H2B type 1-A; Histone H2B, testis; TSH2B.1; Testis-specific histone H2B; HIST1H2BA; TSH2B

Gene Name

HIST1H2BA

UniProt

Q96A08

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

The antiserum was produced against synthesized Acetyl-peptide derived from human H2B around the Acetylation site of Lys126. AA range:78-127

Clonality

Polyclonal

Tissue Specificity

Mainly expressed in testis, and the corresponding protein is also present in mature sperm (at protein level) . Also found in some fat cells. .

Applications

WB, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using a epitope-specific immunogen.

Concentration

1 mg/mL

Form

Liquid

Function

Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones. Also expressed maternally and is present in the female pronucleus, suggesting a similar role in protamine replacement by nucleosomes at fertilization (By similarity) . Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

14167 MW

Gene Name Synonym

Histone H2B type 1-A

Subcellular Location

Nucleus. Chromosome.

Isotype

IgG

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.