Anti-Neuritin NRN1 Antibody

About this product

Boster Bio Anti-Neuritin NRN1 Antibody (Catalog # A09989) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

A09989

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

As the nervous system of a complex organism develops, it establishes functional networks through the growth and retraction of synaptic connections from growing axons and dendrites. This synaptic remodeling involves neuro-transmitter signaling, activation of neurotrophin receptors and alterations in gene expression. One such gene whose expression is increased by neural activity is neuritin, a GPI-anchored protein that is expressed in postmitotic differentiating neurons of the developing nervous system. Its expression is also induced by the neurotrophins BDNF and NT-3. Purified recombinant neuritin promotes neurite outgrowth and arborization in primary embryonic neuronal cultures, suggesting that neuritin may play a role as a downstream effector of activity-induced neurite outgrowth. More recent experiments have shown that neuritin is required for the androgen-induced axonal elongation in motor neurons and is upregulated following spinal cord injury, suggesting that neuritin may also play a role in survival and axonal regeneration.

Synonyms

NRN, dJ380B8.2, NRN, Neuritin

Gene Name

NRN1

UniProt

Q9NPD7

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Neuritin antibody was raised against a 20 amino acid synthetic peptide from near the center of human neuritin. The immunogen is located within amino acids 70 - 120 of Neuritin.

Clonality

Polyclonal

Tissue Specificity

Cerebral cortex.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Neuroscience

Purification

Neuritin Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells. .

Storage Conditions

Neuritin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

15333 MW

Gene Name Synonym

Neuritin 1

Subcellular Location

Cell membrane ; Lipid-anchor, GPI-anchor . Cell junction, synapse .

Prediction Reactivity

Bovine, Rat

Protein Name

Neuritin 1

Isotype

IgG

Contents

Neuritin Antibody is supplied in PBS containing 0.02% sodium azide.