Anti-Uroplakin-1b UPK1B Antibody

About this product

Boster Bio Anti-Uroplakin-1b UPK1B Antibody (Catalog # A10230) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A10230

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Uroplakin-1B (UPK1B) is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. UPK1B is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins and may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.

Synonyms

UPIB, UPK1, TSPAN20, Uroplakin-1b, Tetraspanin-20, UP1b

Gene Name

UPK1B

UniProt

O75841

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

At least two isoforms of UPK1B are known to exist; this antibody will recognize both isoforms. UPK1B antibody is predicted to not cross-react with other tetraspanin protein family members.

Immunogen

UPK1B antibody was raised against a 17 amino acid synthetic peptide near the center of human UPK1B. The immunogen is located within amino acids 110 - 160 of UPK1B.

Clonality

Polyclonal

Tissue Specificity

Bladder epithelium.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Signal Transduction

Purification

UPK1B Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Component of the asymmetric unit membrane (AUM) ; a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity) . .

Storage Conditions

UPK1B antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

29643 MW

Gene Name Synonym

Uroplakin 1B

Subcellular Location

Membrane; Multi-pass membrane protein.

Prediction Reactivity

Bovine

Protein Name

Uroplakin 1B

Isotype

IgG

Contents

UPK1B Antibody is supplied in PBS containing 0.02% sodium azide.