Anti-SESTD1 Antibody

About this product

Boster Bio Anti-SESTD1 Antibody (Catalog # A10698) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A10698

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

SESTD1 was initially identified in mutant zebrafish with defects in the spontaneous contraction and touch response as a novel gene, solo, encoding a protein containing SEC14 and spectrin repeat domains. Other experiments indicated that SESTD1 interacts with the TRPC4 and TRPC5, members of the transient receptor potential channel family, via the TRPC calmodulin- and inositol 1, 4, 5-triphosphate receptor-binding domain and is essential for efficient receptor-mediated activation of TRPC5, suggesting that SESTD1 is a novel regulator of these TRPC proteins.

Synonyms

SOLO, SOLO, SEC14 domain and spectrin repeat-containing protein 1, Huntingtin-interacting protein-like protein

Gene Name

SESTD1

UniProt

Q86VW0

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

SESTD1 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human SESTD1. The immunogen is located within the last 50 amino acids of SESTD1.

Clonality

Polyclonal

Tissue Specificity

Broad expression. High expression in thalamus and brain. Significantly expressed in vasculature.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Signal Transduction

Purification

SESTD1 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1.

Storage Conditions

SESTD1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

79348 MW

Gene Name Synonym

SEC14 and spectrin domains 1

Protein Name

SEC14 and spectrin domains 1

Isotype

IgG

Contents

SESTD1 Antibody is supplied in PBS containing 0.02% sodium azide.