Anti-ECRG4 C2orf40 Antibody

About this product

Boster Bio Anti-ECRG4 C2orf40 Antibody (Catalog # A10864) . Tested in ELISA, WB, ICC applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A10864

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The esophageal cancer-related gene 4 (ECRG4), also known as Augurin, was identified through differential display screening between esophageal cancer and normal tissue. Hypermethylation of CpG sites in the ECRG4 promoter correlate with ECRG4 downregulation in numerous esophageal squamous cell carcinoma tissues.. In transfected cells, overexpression of ECRG4 induced G1 arrest, dephosphorylation of Rb and decreased expression of cyclins D1 and D3. Increased expression of ECRG4 in aged mouse brain is observed compared with young mouse brain. The increased ECRG4 level was accompanied by elevated senescence-associated acidic beta-galactosidase activity, suggesting that ECRG4 is involved in cellular differentiation and senescence.

Synonyms

ECRG4, ECRG4, UNQ761/PRO1508, Augurin, Esophageal cancer-related gene 4 protein

Gene Name

C2ORF40

UniProt

Q9H1Z8

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

ECRG4 antibody is predicted to not cross-react with other ECRG family members.

Immunogen

ECRG4 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human ECRG4. The immunogen is located within the last 50 amino acids of ECRG4.

Clonality

Polyclonal

Applications

ELISA, WB, ICC

Field of Research

Cancer, Cell Cycle

Purification

ECRG4 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Probable hormone that may induce senescence of oligodendrocyte and neural precursor cells, characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation.

Storage Conditions

ECRG4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

17183 MW

Gene Name Synonym

Chromosome 2 open reading frame 40

Subcellular Location

Secreted

Prediction Reactivity

Bovine

Protein Name

Chromosome 2 open reading frame 40

Isotype

IgG

Contents

ECRG4 Antibody is supplied in PBS containing 0.02% sodium azide.