Anti-EFCAB4B CRACR2A Antibody

About this product

Boster Bio Anti-EFCAB4B CRACR2A Antibody (Catalog # A11139) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

A11139

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

EFCAB4B, also known as Calcium release-activated calcium channel regulator 2A, is a novel Ca2+-binding EF-hand protein that is thought to play a key role in store-operated Ca2+ entry in T-cells by regulating CRAC channel activation. EFCAB4B acts as a cytoplasmic calcium-sensor that forms a complex with ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+ concentration. A closely related protein, EFCAB4A, is likely to play a similar role as EFCAB4B, but the detailed function of EFCAB4A is still under investigation.

Synonyms

CRACR2A, CRACR2A, EF-hand calcium-binding domain-containing protein 4B, Calcium release-activated calcium channel regulator 2A, CRAC channel regulator 2A

Gene Name

EFCAB4B

UniProt

Q9BSW2

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

EFCAB4B antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human EFCAB4B. The immunogen is located within amino acids 640 - 690 of EFCAB4B.

Clonality

Polyclonal

Applications

ELISA, WB, IHC-P, IF

Field of Research

Immunology

Purification

EFCAB4B Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Ca (2+) -binding protein that plays a key role in store- operated Ca (2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca (2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca (2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.

Storage Conditions

EFCAB4B antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

45592 MW

Gene Name Synonym

EF-hand calcium binding domain 4B

Subcellular Location

Cytoplasm

Protein Name

EF-hand calcium binding domain 4B

Isotype

IgG

Contents

EFCAB4B Antibody is supplied in PBS containing 0.02% sodium azide.