Anti-CBX6 (K18) Antibody

About this product

Boster Bio Anti-CBX6 (K18) Antibody catalog # A11651. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A11651

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Chromobox protein homolog 6; CBX6

Gene Name

CBX6

UniProt

O95503

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 1-50 of Human CBX6.

Clonality

Polyclonal

Applications

IHC

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530) . PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235) . Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity) . May have a PRC1-independent function in embryonic stem cells (By similarity) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

43898 MW

Applications Notes

IHC: 1:50-1:200

Gene Name Synonym

Chromobox protein homolog 6

Subcellular Location

Nucleus

Protein Name

Chromobox protein homolog 6

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2