Anti-Gem-associated protein 8 GEMIN8 Antibody

About this product

Boster Bio Anti-Gem-associated protein 8 GEMIN8 Antibody catalog # A11881. Tested in WB applications. This antibody reacts with Human.

Specifications

Catalog number

A11881

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Gem-associated protein 8; Gemin-8; Protein FAM51A1; GEMIN8; FAM51A1

Gene Name

GEMIN8

UniProt

Q9NWZ8

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant fusion protein of human GEMIN8 (NP_060326.1) .

Clonality

Polyclonal

Applications

WB

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

28637 MW

Applications Notes

WB: 1:500-1:2000

Gene Name Synonym

Gem-associated protein 8

Subcellular Location

Nucleus, gem

Protein Name

Gem-associated protein 8

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2