Anti-CCDC99 SPDL1 Antibody

Catalog number A12722

Price for A12722

Size / count 100 µL

About this product

Boster Bio Anti-CCDC99 SPDL1 Antibody catalog # A12722. Tested in WB, ELISA applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number: A12722
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
Synonyms: Protein Spindly
Gene Name: SPDL1
UniProt: Q96EA4
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: The antiserum was produced against synthesized peptide derived from human CCDC99. AA range:541-590
Clonality: Polyclonal
Applications: WB, ELISA
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Form: Liquid
Function: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment (PubMed:17576797, PubMed:19468067) . Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494) .
Storage Conditions: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight: 70172 MW
Gene Name Synonym: Protein Spindly
Subcellular Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Localizes to the nucleus in interphase and to the kinetochore in early prometaphase. Relocalizes to the mitotic spindle pole before metaphase and is subsequently lost from the spindle poles after chromosome congression is completed. Removal of this protein from the kinetochore requires the dynein/dynactin complex.
Protein Name: Protein Spindly
Isotype: IgG
Contents: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Frequently Asked Questions

What is the catalog number for Anti-CCDC99 SPDL1 Antibody?

The catalog number for Anti-CCDC99 SPDL1 Antibody is A12722.

What sizes are available for Anti-CCDC99 SPDL1 Antibody?

Anti-CCDC99 SPDL1 Antibody is available in the following size(s): 100 µL.

Is Anti-CCDC99 SPDL1 Antibody in stock?

Anti-CCDC99 SPDL1 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for Anti-CCDC99 SPDL1 Antibody?

The safety data sheet for Anti-CCDC99 SPDL1 Antibody is available here: https://www.bosterbio.com/msds?sku=A12722.

What is Anti-CCDC99 SPDL1 Antibody used for?

Boster Bio Anti-CCDC99 SPDL1 Antibody catalog # A12722. Tested in WB, ELISA applications. This antibody reacts with Human, Mouse, Rat.

Does this cell line or biologic require a Material Transfer Agreement (MTA)?

Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.