Anti-Lano LRRC1 Antibody

About this product

Boster Bio Anti-Lano LRRC1 Antibody (Catalog # A13956) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.

Specifications

Catalog number

A13956

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Lano is a member of the LAP (leucine-rich repeats and PDZ) family of proteins that also includes Densin-180, Erbin, and hScribble. The LAP proteins generally contain multiple leucine-rich repeat (LRR) domains which serve to target them to the basolateral membrane of epithelial cells. Lano is unique in that it alone does not possess one or more PDZ (PSD95/DLG/ZO-1) domains as do the other members of the LAP family. However, it can bind to the PDZ domain of Erbin in addition to those of membrane-associated and guanylate kinase (MAGUK) proteins which regulate adhesion and plasticity at cell junctions. It has been suggested that it is through these interaction that these LAP proteins participate in the maintenance of proper embryonic development and integrity of epithelial tissues.

Synonyms

LANO, dJ523E19.1, LANO, Leucine-rich repeat-containing protein 1, LANO adapter protein

Gene Name

LRRC1

UniProt

Q9BTT6

Host

Rabbit

Reactivity

Human

Immunogen

Lano antibody was raised against a peptide corresponding to 15 amino acids near the carboxy terminus of human Lano. The immunogen is located within the last 50 amino acids of Lano.

Clonality

Polyclonal

Tissue Specificity

Expressed strongly in testis and placenta, followed by heart, lung, kidney, thyroid, trachea, colon, prostate and pancreas.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Immunology, Neuroscience, Growth Factors

Purification

Lano Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561) . Component of an autophagy-mediated antibacterial pathway together with ATG16L1 (PubMed:20637199) . Plays also a role in sensing single-stranded RNA (ssRNA) from viruses. Interacts with mitochondrial antiviral signaling/MAVS, leading to activation of interferon regulatory factor-3/IRF3 and expression of type I interferon (PubMed:19701189) .

Storage Conditions

Lano antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

59242 MW

Gene Name Synonym

Leucine rich repeat containing 1

Subcellular Location

Cytoplasm

Prediction Reactivity

Mouse

Protein Name

Leucine rich repeat containing 1

Isotype

IgG

Contents

Lano Antibody is supplied in PBS containing 0.02% sodium azide.