Anti-COX6A2 Antibody (Center)

About this product

Boster Bio Anti-COX6A2 Antibody (Center) (Catalog # A15662-2) . Tested in IHC-P, WB application (s) . This antibody reacts with Human.

Specifications

Catalog number

A15662-2-400ul

Size / count

400 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (heart/muscle isoform) of subunit VIa, and polypeptide 2 is present only in striated muscles. Polypeptide 1 (liver isoform) of subunit VIa is encoded by a different gene, and is found in all non-muscle tissues. These two polypeptides share 66% amino acid sequence identity.

Synonyms

Cytochrome c oxidase subunit 6A2, mitochondrial, Cytochrome c oxidase polypeptide VIa-heart, COXVIAH, Cytochrome c oxidase subunit VIA-muscle, COX VIa-M, COX6A2, COX6A, COX6AH

Gene Name

COX6A2

UniProt

Q02221

Host

Rabbit

Reactivity

Human

Immunogen

This COX6A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-66 amino acids from the Central region of human COX6A2.

Clonality

Polyclonal

Tissue Specificity

Expressed specifically in heart and muscle (PubMed:31155743) . Not detected in brain, colon, spleen, kidney, liver, lung and pancreas (PubMed:31155743) .

Applications

IHC-P, WB

Field of Research

Signal Transduction, Mitochondria

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

31155743

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

10815 Da

Subcellular Location

Mitochondrion inner membrane {ECO:0000250|UniProtKB:P07471}; Single-pass membrane protein {ECO:0000250|UniProtKB:P07471}

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.