Anti-CTRP2 C1QTNF2 Antibody

About this product

Boster Bio Anti-CTRP2 C1QTNF2 Antibody (Catalog # A16305) . Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

A16305

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. Of the CTRPs, CTRP2 is most similar structurally and functionally to adiponectin. Recombinant CTRP2 rapidly activated AMPK and MAPK in cultured C2C12 cells, leading to increased glycogen accumulation and fatty acid oxidation.

Synonyms

CTRP2, zacrp2, CTRP2, UNQ6349/PRO21054, Complement C1q tumor necrosis factor-related protein 2

Gene Name

C1QTNF2

UniProt

Q9BXJ5

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

These proteins are often highly modified post-translationally and migrate in SDS-PAGE at positions other than their predicted size.

Immunogen

Rabbit CTRP2 polyclonal antibody was raised against a 16 amino acid synthetic peptide from near the center of human CTRP2. The immunogen is located within amino acids 140 - 190 of CTRP2.

Clonality

Polyclonal

Tissue Specificity

Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta.

Applications

ELISA, WB, IHC-P

Field of Research

Signal Transduction

Purification

CTRP2 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400) . Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:15340059) . May also play a role in microtubule-mediated protein transport (By similarity) . Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity) .

Storage Conditions

CTRP2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

29952 MW

Gene Name Synonym

C1q and tumor necrosis factor related protein 2

Subcellular Location

Secreted .

Protein Name

C1q and tumor necrosis factor related protein 2

Isotype

IgG

Contents

CTRP2 Antibody is supplied in PBS containing 0.02% sodium azide.