Anti-IKAP ELP1 Antibody

About this product

Boster Bio Anti-IKAP ELP1 Antibody (Catalog # A31687) . Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

A31687

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

IKAP was initially identified as a scaffold protein of the IκB kinase complex that could bind to IKKα , IKKβ , NF-κB, and the NF-κB-inducing kinase (NIK), although later evidence has cast doubt on this. More recent reports show that mutations in IKAP such as a frameshift leading to a truncated protein or a missense mutation that leads to defective phosphorylation are responsible for the autosomal recessive genetic disease familial dysautonomia (FD) . Reports indicating that it forms part of the RNA polymerase II transcription elongation complex suggest that this disease may be due to compromised transcription elongation. More recently, it was shown that IKAP associates with c-Jun N-terminal kinase (JNK) and could specifically enhance JNK activation induced by the upstream JNK activators MEKK1 and ASK1, indicating another possible cause for FD.

Synonyms

FD, DYS, ELP1, IKAP, IKI3, TOT1, Elongator complex protein 1, IkappaB kinase complex-associated protein

Gene Name

IKBKAP

UniProt

O95163

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

At least two isoforms of IKAP are known two exist, this antibody will detect both isoforms.

Immunogen

IKAP antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human IKAP. The immunogen is located within the last 50 amino acids of IKAP.

Clonality

Polyclonal

Tissue Specificity

Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Applications

ELISA, WB, ICC, IF

Field of Research

Signal Transduction

Purification

IKAP Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) .

Storage Conditions

IKAP antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

150254 MW

Gene Name Synonym

Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein

Subcellular Location

Cytoplasm

Prediction Reactivity

Rabbit, Rat

Protein Name

Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein

Isotype

IgG

Contents

IKAP Antibody is supplied in PBS containing 0.02% sodium azide.