Anti-SOX2 Antibody

About this product

Boster Bio Anti-SOX2 Antibody (Catalog # M00105-3) . Tested in WB, IF, Flow Cytometry, IHC-P application (s) . This antibody reacts with Human.

Specifications

Catalog number

M00105-3-80ul

Size / count

80 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT) .

Synonyms

Transcription factor SOX-2, SOX2

Gene Name

SOX2

UniProt

P48431

Host

Mouse

Reactivity

Human

Immunogen

SOX2 recombinant protein is used to produce this monoclonal antibody.

Clonality

Monoclonal

Clone

Clone: 57CT23.3.4

Applications

WB, IF, Flow Cytometry, IHC-P

Field of Research

Developmental Biology, Neuroscience, Signal Transduction

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

18035408

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

34310 Da

Subcellular Location

Nucleus speckle {ECO:0000250|UniProtKB:Q05066}. Cytoplasm {ECO:0000250|UniProtKB:Q05738}. Nucleus {ECO:0000250|UniProtKB:Q05738}. Note=Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization (By similarity) . Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity) Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus (By similarity) . Nuclear import is facilitated by XPO4, a protein that usually acts as a nuclear export signal receptor (By similarity) {ECO:0000250|UniProtKB:Q05066, ECO:0000250|UniProtKB:Q05738}

Isotype

IgG1

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.