Anti-KLF4 Antibody

About this product

Boster Bio Anti-KLF4 Antibody (Catalog # M00120-2) . Tested in WB application (s) . This antibody reacts with Human, Mouse.

Specifications

Catalog number

M00120-2-200ul

Size / count

200 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.

Synonyms

Krueppel-like factor 4, Epithelial zinc finger protein EZF, Gut-enriched krueppel-like factor, KLF4, EZF, GKLF

Gene Name

KLF4

UniProt

O43474

Host

Mouse

Reactivity

Human, Mouse

Immunogen

This KLF4 antibody is generated from a mouse immunized with a recombinant protein from the human region of human KLF4.

Clonality

Monoclonal

Clone

Clone: 2000CT726.79.22

Applications

WB

Field of Research

Cancer, Cardiovascular, Developmental Biology, Neuroscience, Stem Cells

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

54671 Da

Applications Notes

WB: 1:500-1:1000

Subcellular Location

Nucleus {ECO:0000250|UniProtKB:Q60793}. Cytoplasm {ECO:0000250|UniProtKB:Q60793}

Prediction Reactivity

Human

Isotype

IgG1, κ

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.