Anti-TLR2 Antibody

About this product

Boster Bio Anti-TLR2 Antibody (Catalog # M00131-1) . Tested in WB application (s) . This antibody reacts with Human.

Specifications

Catalog number

M00131-1-200ul

Size / count

200 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.

Synonyms

Toll-like receptor 2, Toll/interleukin-1 receptor-like protein 4, CD282, TLR2, TIL4

Gene Name

TLR2

UniProt

O60603

Host

Mouse

Reactivity

Human

Immunogen

This TLR2 Antibody is generated from a mouse immunized with a recombinant protein .

Clonality

Monoclonal

Clone

Clone: 1070CT4.2.3.2

Tissue Specificity

Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues

Applications

WB

Field of Research

Cardiovascular, Immunology, Microbiology, Signal Transduction, Inflammation, Innate Immunity, TLR Signaling

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

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Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

89838 Da

Applications Notes

WB: 1:500-1:1000

Subcellular Location

Membrane {ECO:0000250|UniProtKB:Q9QUN7}; Single- pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9QUN7}; Single-pass type I membrane protein. Membrane raft. Note=Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment determines the intracellular targeting to the Golgi apparatus. Triacylated lipoproteins induce the same mechanism for TLR2:TLR1 heterodimers.

Isotype

IgG1, κ

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.