Anti-CCND1 Antibody

Catalog number M00149-50ul

Price for M00149-50ul

Size / count 50 µL

About this product

Boster Bio Anti-CCND1 Antibody (Catalog # M00149) . Tested in WB application (s) . This antibody reacts with Human, Mouse.

Specifications

Catalog number: M00149-50ul
Size / count: 50 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G (1) /S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G (1) phase. Hypophosphorylates RB1 in early G (1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.
Synonyms: G1/S-specific cyclin-D1, B-cell lymphoma 1 protein, BCL-1, BCL-1 oncogene, PRAD1 oncogene, CCND1, BCL1, PRAD1
Gene Name: CCND1
UniProt: P24385
Host: Mouse
Reactivity: Human, Mouse
Immunogen: This antibody is generated from a mouse immunized with a recombinant protein from human.
Clonality: Monoclonal
Clone: Clone: 1849CT557.93.5
Applications: WB
Field of Research: Cancer, Cell Biology, Anti-Wnt-Pathway (plus Lgr5) Antibodies
Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.
Function: 18330661827756811473983026051941216233854235183306618277568114739830260519412162183306618277568114739830260519412162183306618277568302605194121621524141891066571656921518417529
Storage Conditions: Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Observed Molecular Weight: 33729 Da
Applications Notes: WB: 1:2000
Subcellular Location: Nucleus. Cytoplasm Nucleus membrane. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members
Prediction Reactivity: Human
Isotype: IgG1, κ
Contents: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Frequently Asked Questions

What is the catalog number for Anti-CCND1 Antibody?

The catalog number for Anti-CCND1 Antibody is M00149-50ul.

What sizes are available for Anti-CCND1 Antibody?

Anti-CCND1 Antibody is available in the following size(s): 50 µL.

Is Anti-CCND1 Antibody in stock?

Anti-CCND1 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for Anti-CCND1 Antibody?

The safety data sheet for Anti-CCND1 Antibody is available here: https://www.bosterbio.com/msds?sku=M00149.

What is Anti-CCND1 Antibody used for?

Boster Bio Anti-CCND1 Antibody (Catalog # M00149) . Tested in WB application (s) . This antibody reacts with Human, Mouse.

What is the sensitivity of this ELISA kit?

Assay sensitivity, including the minimum detectable dose, is listed on the datasheet. Kits that are assembled on order typically ship within 2-4 weeks.

Do you ship this product with dry ice?

Some products, including certain cell lines and biologics, require dry ice for transportation, which carries an additional fee shown clearly in your quotation. Dry ice delivery isn’t always possible to every destination due to transit time or local restrictions, so we check feasibility in advance and you must store the goods at the correct temperature the moment they arrive.

Is this product species cross-reactive?

Cross-reactivity data, based on available testing, is listed under the reactivity section of the datasheet. Contact us if you need reactivity confirmed for a species not listed.