Anti-SNCA Antibody (C-term)

About this product

Boster Bio Anti-SNCA Antibody (C-term) (Catalog # M00215-2) . Tested in WB, IHC-P, Flow Cytometry application (s) . This antibody reacts with Human.

Specifications

Catalog number

M00215-2-400ul

Size / count

400 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.

Synonyms

Alpha-synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, NACP, SNCA, NACP, PARK1

Gene Name

SNCA

UniProt

P37840

Host

Rabbit

Reactivity

Human

Immunogen

This SNCA antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 92-125 amino acids from the C-terminal region of human SNCA.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in presynaptic terminals in the central nervous system. Expressed principally in brain

Applications

WB, IHC-P, Flow Cytometry

Field of Research

Neuroscience

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

28288128304048282079828226442590282881283040482830404828207982822079828226442590

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

14460 Da

Subcellular Location

Cytoplasm. Membrane. Nucleus. Synapse Secreted. Cell projection, axon {ECO:0000250|UniProtKB:O55042}. Note=Membrane-bound in dopaminergic neurons (PubMed:15282274) . Expressed and colocalized with SEPTIN4 in dopaminergic axon terminals, especially at the varicosities (By similarity) . {ECO:0000250|UniProtKB:O55042, ECO:0000269|PubMed:15282274}

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.