Anti-TTN Antibody (N-term)

About this product

Boster Bio Anti-TTN Antibody (N-term) (Catalog # M00540) . Tested in IHC-P application (s) . This antibody reacts with Human.

Specifications

Catalog number

M00540-200ul

Size / count

200 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.

Synonyms

Titin, 2.7.11.1, Connectin, Rhabdomyosarcoma antigen MU-RMS-40.14, TTN

Gene Name

TTN

UniProt

Q8WZ42

Host

Rabbit

Reactivity

Human

Immunogen

This TTN antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 7169-7203 amino acids from the N-terminal region of human TTN.

Clonality

Polyclonal

Tissue Specificity

Isoforms 3, 7 and 8 are expressed in cardiac muscle. Isoform 4 is expressed in vertebrate skeletal muscle. Isoform 6 is expressed in skeletal muscle (at protein level)

Applications

IHC-P

Field of Research

Cardiovascular, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

3816030 Da

Applications Notes

IHC-P: 1:500

Subcellular Location

Cytoplasm. Nucleus

Prediction Reactivity

Mouse

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.