Anti-ALDH2 Antibody

About this product

Boster Bio Anti-ALDH2 Antibody (Catalog # M00546-4) . Tested in WB, IF, Flow Cytometry, IHC-P application (s) . This antibody reacts with Human.

Specifications

Catalog number

M00546-4-80ul

Size / count

80 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix.

Synonyms

Aldehyde dehydrogenase, mitochondrial, ALDH class 2, ALDH-E2, ALDHI, ALDH2, ALDM

Gene Name

ALDH2

UniProt

P05091

Host

Mouse

Reactivity

Human

Immunogen

This ALDH2 Monoclonal antibody is generated from mouse immunized with ALDH2 recombinant protein.

Clonality

Monoclonal

Clone

Clone: 138CT22.3.8

Applications

WB, IF, Flow Cytometry, IHC-P

Field of Research

Cardiovascular, Metabolism, Signal Transduction, Mitochondria

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

56381 Da

Subcellular Location

Mitochondrion matrix.

Isotype

IgG1, Igκ

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.