Anti-Mouse Med12 Antibody (C-term)

About this product

Boster Bio Anti-Mouse Med12 Antibody (C-term) (Catalog # M00828) . Tested in WB, IHC-P application (s) . This antibody reacts with Human, Mouse.

Specifications

Catalog number

M00828-80ul

Size / count

80 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway (By similarity) .

Synonyms

Mediator of RNA polymerase II transcription subunit 12, Mediator complex subunit 12, OPA-containing protein, Thyroid hormone receptor-associated protein complex 230 kDa component, Trap230, Trinucleotide repeat-containing gene 11 protein, Med12, Kiaa0192, Mopa, Tnrc11, Trap230

Gene Name

Med12

UniProt

A2AGH6

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This Mouse Med12 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1991-2025 amino acids from the C-terminal region of Mouse Med12.

Clonality

Polyclonal

Applications

WB, IHC-P

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway (By similarity) .

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

244561 Da

Subcellular Location

Nucleus.

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.