Anti-CALR Antibody (Center)

About this product

Boster Bio Anti-CALR Antibody (Center) (Catalog # M00894-1) . Tested in WB application (s) . This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

M00894-1-50ul

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity) .

Synonyms

HGNC:1455

Gene Name

CALR

UniProt

P27797

Host

Mouse

Reactivity

Human, Mouse, Rat

Immunogen

This CALR antibody is generated from a mouse immunized with a recombinant protein from human CALR.

Clonality

Monoclonal

Clone

Clone: 2143CT58.2.1

Applications

WB

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

787624611149926

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

48142 Da

Applications Notes

WB: 1:500

Subcellular Location

Endoplasmic reticulum lumen. Cytoplasm, cytosol. Secreted, extracellular space, extracellular matrix. Cell surface. Sarcoplasmic reticulum lumen {ECO:0000250|UniProtKB:P28491}. Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000250|UniProtKB:Q8K3H7}. Cytolytic granule. Note=Also found in cell surface (T cells), cytosol and extracellular matrix (PubMed:10358038) . During oocyte maturation and after parthenogenetic activation accumulates in cortical granules. In pronuclear and early cleaved embryos localizes weakly to cytoplasm around nucleus and more strongly in the region near the cortex (By similarity) . In cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation (By similarity) . {ECO:0000250|UniProtKB:P28491, ECO:0000250|UniProtKB:Q8K3H7, ECO:0000269|PubMed:8418194}

Prediction Reactivity

Human

Isotype

IgG1, κ

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.