Anti-ORAI1 Monoclonal Antibody [3F6H5]

About this product

Boster Bio Anti-ORAI1 Monoclonal Antibody [3F6H5] (Catalog # M00909) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

M00909

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one fo rm of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. ORAI1 often migrates at a higher than expected molecular weight in SDS-PAGE. This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.

Synonyms

IMD9, ORAT1, CRACM1, TMEM142A

Gene Name

ORAI1

UniProt

Q96D31

Host

Mouse

Reactivity

Human, Mouse, Rat

Cross Reactivity

ORAI1 antibody is predicted to have no cross reactivity to other members in the ORAI family.

Immunogen

Mouse monoclonal ORAI1 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human ORAI1.

Clonality

Monoclonal

Clone

Clone: Clone: 3F6H5

Applications

ELISA, WB, IHC-P, IF

Field of Research

Immunology

Purification

ORAI1 Monoclonal Antibody is Protein A purified.

Concentration

1 mg/mL

Form

Liquid

Function

Ca (2+) release-activated Ca (2+) (CRAC) channel subunit which mediates Ca (2+) influx following depletion of intracellular Ca (2+) stores and channel activation by the Ca (2+) sensor, STIM1 (PubMed:16582901, PubMed:16645049, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:19249086, PubMed:23307288, PubMed:24351972, PubMed:24591628, PubMed:28219928) . CRAC channels are the main pathway for Ca (2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (PubMed:16582901) .

Storage Conditions

ORAI1 monoclonal antibody can be stored at -20°C, stable for one year.

Observed Molecular Weight

32668 MW

Gene Name Synonym

ORAI calcium release-activated calcium modulator 1

Subcellular Location

Cell membrane

Protein Name

ORAI calcium release-activated calcium modulator 1

Isotype

IgG1

Contents

ORAI1 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.