- Catalog number
- M01005-80ul
- Size / count
- 80 µL
- Dry ice
- No
- Hazardous
- No
- Discontinued
- No
- Background
- G-protein coupled receptor for 5-hydroxytryptamine (serotonin) . Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1- (2,5- dimethoxy-4-iodophenyl) -2-aminopropane (DOI) and lysergic acid diethylamide (LSD) . Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca (2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
- Synonyms
- 5-hydroxytryptamine receptor 2A, 5-HT-2, 5-HT-2A, Serotonin receptor 2A, Htr2a, Htr2
- Gene Name
- Htr2a
- UniProt
- P35363
- Host
- Rabbit
- Reactivity
- Mouse
- Immunogen
- This Htr2a antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 16-30 amino acids from the N-terminal region of human Htr2a.
- Clonality
- Polyclonal
- Tissue Specificity
- Detected in neurons in brain cortex. Detected in adult intestine, especially in mucosal epithelium, longitudinal and circular layers of muscularis externa and myenteric plexuses. Highly expressed in Paneth cells, and detected at lower levels in enterocytes (at protein level) . Detected in neurons in the brain cortex
- Applications
- WB, IHC-P
- Purification
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Function
- G-protein coupled receptor for 5-hydroxytryptamine (serotonin) . Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1- (2,5- dimethoxy-4-iodophenyl) -2-aminopropane (DOI) and lysergic acid diethylamide (LSD) . Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca (2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
- Storage Conditions
- Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
- Observed Molecular Weight
- 52842 Da
- Subcellular Location
- Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, axon {ECO:0000250|UniProtKB:P14842}. Cytoplasmic vesicle. Membrane, caveola {ECO:0000250|UniProtKB:P14842}. Presynapse {ECO:0000250|UniProtKB:P14842}
- Isotype
- Rabbit IgG
- Contents
- Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
