Anti-CBX3 (5G10) monoclonal Antibody

About this product

Boster Bio Anti-CBX3 (5G10) monoclonal Antibody catalog # M01142. Tested in WB, ICC, IHC, IP applications. This antibody reacts with Human, Mouse, Rat, Monkey.

Specifications

Catalog number

M01142

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Chromobox protein homolog 3; HECH; Heterochromatin protein 1 homolog gamma; HP1 gamma; Modifier 2 protein; CBX3

Gene Name

CBX3

UniProt

Q13185

Host

Mouse

Reactivity

Human, Mouse, Rat, Monkey

Immunogen

Purified recombinant human CBX3 protein fragments expressed in E.coli.

Clonality

Monoclonal

Applications

WB, ICC, IHC, IP

Purification

The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR) . Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitement of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

20811 MW

Gene Name Synonym

Chromobox protein homolog 3

Subcellular Location

Nucleus . Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential) . .

Protein Name

Chromobox protein homolog 3

Contents

1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2