Anti-Hu CD1c Purified Monoclonal Antibody

About this product

Boster Bio Anti-Hu CD1c Purified Monoclonal Antibody (Catalog# M01188) . Tested in Flow Cytometry, IP, IHC application (s) . This antibody reacts with Human.

Specifications

Catalog number

M01188

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD1c (also known as R7 or BDCA1) together with CD1a and b, belongs to group 1 of CD1 antigens. These non-classical MHC-like glycoproteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. The trafficking routes of the particular CD1 types differ and correspond to their ability to bind and present different groups of antigens. CD1c is unique in its ability to present e.g. mycobacterial phosphoketides and polyisoprenoids. CD1c is the only CD1 isoform that has been shown to interact both with alpha/beta and gamma/delta T cells.

Synonyms

R7, BDCA1

Gene Name

CD1C

UniProt

P29017

Host

Mouse

Reactivity

Human

Immunogen

Human thymocytes. The mouse monoclonal antibody L161 recognizes an extracellular epitope of CD1c, (R7), a 43 kDa type I glycoprotein associated with beta2-microglobulin. It is expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells, B and some T cells.

Clonality

Monoclonal

Clone

Clone: L161

Tissue Specificity

Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.

Applications

Flow Cytometry, IP, IHC

Purification

Purified by protein-A affinity chromatography.

Concentration

1 mg/mL

Form

Liquid

Function

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

Storage Conditions

Store at 2-8°C. Do not freeze.

Observed Molecular Weight

37654 MW

Applications Notes

Flow cytometry: 1-4 μg/mL.

Gene Name Synonym

CD1c molecule

Subcellular Location

Cell membrane

Protein Name

T-cell surface glycoprotein CD1c

Isotype

Mouse IgG1 kappa

Contents

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide