Product details

Anti-FHIT Antibody

Catalog number M01200-1-80ul

Price for M01200-1-80ul

Size / count 80 µL

About this product

Boster Bio Anti-FHIT Antibody (Catalog # M01200-1) . Tested in WB, Flow Cytometry application (s) . This antibody reacts with Human.

Specifications

Catalog number: M01200-1-80ul
Size / count: 80 µL
Dry ice: No
Hazardous: No
Discontinued: No
Background: Cleaves P (1) -P (3) -bis (5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P (1) -P (4) -bis (5'- adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P (1) -P (3) -bis (5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low- affinity Ca (2+) transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor.
Synonyms: Bis (5'-adenosyl) -triphosphatase, AP3A hydrolase, AP3Aase, Diadenosine 5',5'''-P1, P3-triphosphate hydrolase, Dinucleosidetriphosphatase, Fragile histidine triad protein, FHIT
Gene Name: FHIT
UniProt: P49789
Host: Mouse
Reactivity: Human
Immunogen: This FHIT antibody is generated from a mouse immunized with a recombinant protein.
Clonality: Monoclonal
Clone: Clone: 1093CT23.1.2
Tissue Specificity: Low levels expressed in all tissues tested. Phospho-FHIT observed in liver and kidney, but not in brain and lung Phospho-FHIT undetected in all tested human tumor cell lines
Applications: WB, Flow Cytometry
Field of Research: Mitochondria
Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.
Function: 12574506151822068794732932320795769089543008125745061518220687947329323207957690895430088794732186947471869474726181368261813681807732616407838153139151257450619622739
Storage Conditions: Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Observed Molecular Weight: 16858 Da
Subcellular Location: Cytoplasm. Mitochondrion. Nucleus
Isotype: IgG1, k
Contents: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Frequently Asked Questions

What is the catalog number for Anti-FHIT Antibody?

The catalog number for Anti-FHIT Antibody is M01200-1-80ul.

What sizes are available for Anti-FHIT Antibody?

Anti-FHIT Antibody is available in the following size(s): 80 µL.

Is Anti-FHIT Antibody in stock?

Anti-FHIT Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for Anti-FHIT Antibody?

The safety data sheet for Anti-FHIT Antibody is available here: https://www.bosterbio.com/msds?sku=M01200-1.

What is Anti-FHIT Antibody used for?

Boster Bio Anti-FHIT Antibody (Catalog # M01200-1) . Tested in WB, Flow Cytometry application (s) . This antibody reacts with Human.

What dilution range is recommended for immunohistochemistry (IHC) with this antibody?

A starting IHC dilution range is listed on the datasheet, but should be optimized for your specific tissue type and staining protocol.

Can I request a Safety Data Sheet (SDS) for this product?

Yes, safety data sheets are available for hazardous or chemically classified products and can be provided on request or downloaded from the product page.

Can this product be used for co-immunoprecipitation (Co-IP)?

Suitability for Co-IP depends on the specific antibody and is noted under validated applications on the datasheet. If it isn’t listed, contact our technical support team for guidance based on your target and sample type.