Anti-Flt-4 Monoclonal Antibody

About this product

Boster Bio Anti-Flt-4 Monoclonal Antibody catalog # M01276. Tested in WB, ELISA applications. This antibody reacts with Human.

Specifications

Catalog number

M01276

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Vascular endothelial growth factor receptor 3; VEGFR-3;2.7.10.1; Fms-like tyrosine kinase 4; FLT-4; Tyrosine-protein kinase receptor FLT4; FLT4; VEGFR3

Gene Name

FLT4

UniProt

P35916

Host

Mouse

Reactivity

Human

Immunogen

Purified recombinant fragment of human Flt-4 expressed in E. Coli.

Clonality

Monoclonal

Clone

Clone: 4H4

Tissue Specificity

Detected in endothelial cells (at protein level) . Widely expressed. Detected in fetal spleen, lung and brain. Detected in adult liver, muscle, thymus, placenta, lung, testis, ovary, prostate, heart, and kidney.

Applications

WB, ELISA

Purification

Affinity purification

Concentration

1 mg/mL

Form

Liquid

Function

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr- 185', and of AKT1 at 'Ser-473'.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

152757 MW

Gene Name Synonym

Vascular endothelial growth factor receptor 3

Subcellular Location

Cell membrane

Protein Name

Vascular endothelial growth factor receptor 3

Isotype

IgG

Contents

Ascitic fluid containing 0.03% sodium azide.