Anti-GOLPH3 Antibody (C-term)

About this product

Boster Bio Anti-GOLPH3 Antibody (C-term) (Catalog # M01333) . Tested in WB application (s) . This antibody reacts with Human.

Specifications

Catalog number

M01333-400ul

Size / count

400 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their cytosolic domains. Involved in modulation of mTOR signaling. Involved in the regulation of mitochondrial lipids, leading to increase of mitochondrial mass. Potential oncogene.

Synonyms

Golgi phosphoprotein 3, Coat protein GPP34, Mitochondrial DNA absence factor, MIDAS, GOLPH3, GPP34

Gene Name

GOLPH3

UniProt

Q9H4A6

Host

Mouse

Reactivity

Human

Immunogen

Purified His-tagged GOLPH3 protein was used to produced this monoclonal antibody.

Clonality

Monoclonal

Clone

Clone: 905CT9.1.1

Tissue Specificity

Detected in muscle fibers of patients with mitochondrial diseases; not detected in normal muscle fibers

Applications

WB

Field of Research

Signal Transduction, Mitochondria

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

33811 Da

Applications Notes

WB: 1:1000

Subcellular Location

Golgi apparatus, Golgi stack membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side Mitochondrion intermembrane space. Cell membrane Endosome. Note=Phosphatidylinositol 4-phosphate-binding and oligomerization participate in the recruitment onto Golgi membranes.

Isotype

IgG1

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.