Anti-SLUG SNAI2 Monoclonal Antibody

About this product

Boster Bio Anti-SLUG SNAI2 Monoclonal Antibody catalog # M01615. Tested in WB, ELISA applications. This antibody reacts with Human.

Specifications

Catalog number

M01615

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Zinc finger protein SNAI2; Neural crest transcription factor Slug; Protein snail homolog 2; SNAI2; SLUG, SLUGH

Gene Name

SNAI2

UniProt

O43623

Host

Mouse

Reactivity

Human

Immunogen

Purified recombinant fragment of human SLUG expressed in E. Coli.

Clonality

Monoclonal

Clone

Clone: 2H5

Tissue Specificity

Expressed in most adult human tissues, including spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not detected in peripheral blood leukocyte. Expressed in the dermis and in all layers of the epidermis, with high levels of expression in the basal layers (at protein level) . Expressed in osteoblasts (at protein level) . Expressed in mesenchymal stem cells (at protein level) . Expressed in breast tumor cells (at protein level) .

Applications

WB, ELISA

Purification

Affinity purification

Concentration

1 mg/mL

Form

Liquid

Function

Transcriptional repressor that modulates both activator- dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1- induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity) . Represses BRCA2 expression by binding to its E2- box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

29986 MW

Gene Name Synonym

Zinc finger protein SNAI2

Subcellular Location

Nucleus

Protein Name

Zinc finger protein SNAI2

Isotype

IgG

Contents

Ascitic fluid containing 0.03% sodium azide.