Anti-ABCB4 Antibody

About this product

Boster Bio Anti-ABCB4 Antibody (Catalog # M01669) . Tested in WB application (s) . This antibody reacts with Human.

Specifications

Catalog number

M01669-50ul

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte.

Synonyms

Multidrug resistance protein 3, 3.6.3.44, ATP-binding cassette sub-family B member 4, P-glycoprotein 3, ABCB4, MDR3, PGY3

Gene Name

ABCB4

UniProt

P21439

Host

Mouse

Reactivity

Human

Immunogen

This ABCB4 antibody is generated from a mouse immunized with a recombinant protein of human ABCB4.

Clonality

Monoclonal

Clone

Clone: 1808CT346.21.23

Applications

WB

Field of Research

Metabolism, Signal Transduction

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

79579368898203936657117523162234681322480675424723470245946352182039031873305234681322404584093665712801225821820390

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

141523 Da

Applications Notes

WB: 1:4000

Subcellular Location

Cell membrane; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}. Apical cell membrane; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}. Membrane raft. Cytoplasm Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q08201}. Note=Localized at the apical canalicular membrane of the epithelial cells lining the lumen of the bile canaliculi and biliary ductules (By similarity) . Transported from the Golgi to the apical bile canalicular membrane in a RACK1-dependent manner (PubMed:19674157) . Redistributed into pseudocanaliculi formed between cells in a bezafibrate- or PPARA-dependent manner (PubMed:15258199) . Localized preferentially in lipid nonraft domains of canalicular plasma membranes (PubMed:23468132) {ECO:0000250|UniProtKB:P21440, ECO:0000269|PubMed:15258199, ECO:0000269|PubMed:19674157, ECO:0000269|PubMed:23468132}

Isotype

IgG1, k

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.