Anti-SorLA SORL1 Monoclonal Antibody

About this product

Boster Bio Anti-SorLA SORL1 Monoclonal Antibody catalog # M01887. Tested in WB, IHC, IF, ELISA applications. This antibody reacts with Human.

Specifications

Catalog number

M01887

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Sortilin-related receptor; Low-density lipoprotein receptor relative with 11 ligand-binding repeats; LDLR relative with 11 ligand-binding repeats; LR11; SorLA-1; Sorting protein-related receptor containing LDLR class A repeats; SorLA; SORL1; C11orf32

Gene Name

SORL1

UniProt

Q92673

Host

Mouse

Reactivity

Human

Immunogen

Purified recombinant fragment of human SorLA expressed in E. Coli.

Clonality

Monoclonal

Clone

Clone: 3B6B11

Tissue Specificity

Expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole; low expression in the putamen and the thalamus. Expression is significantly reduced in the frontal cortex of patients suffering from Alzheimer disease. According to PubMed:9157966, found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. According to PubMed:8940146, expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals.

Applications

WB, IHC, IF, ELISA

Purification

Affinity purification

Concentration

1 mg/mL

Form

Liquid

Function

Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor- associated protein (RAP) . Could play a role in cell-cell interaction. Involved in APP trafficking to and from the Golgi apparatus. It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta, thereby reducing the burden of amyloidogenic peptide formation. Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

248426 MW

Gene Name Synonym

Sortilin-related receptor

Subcellular Location

Membrane ; Single-pass type I membrane protein . Golgi apparatus. Endosome. Secreted.

Protein Name

Sortilin-related receptor

Isotype

IgG

Contents

Ascitic fluid containing 0.03% sodium azide.