Anti-SLC22A1 Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-SLC22A1 Rabbit Monoclonal Antibody catalog # M01945. Tested in IHC, IF, WB applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

M01945

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Solute carrier family 22 member 1; Organic cation transporter 1; hOCT1; SLC22A1; OCT1

Gene Name

SLC22A1

UniProt

O15245

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthesized peptide derived from human OCT1 Monoclonal Antibody

Clonality

Monoclonal

Tissue Specificity

Widely expressed with high level in liver. Isoform 1 and isoform 2 are expressed in liver. Isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in glial cell lines.

Applications

IHC, IF, WB

Purification

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration

1 mg/mL

Form

Liquid

Function

Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4- (4- (dimethylamino) styryl) - N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin- dependent kinase II and LCK tyrosine kinase.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

61154 MW

Gene Name Synonym

Solute carrier family 22 member 1

Subcellular Location

Basolateral cell membrane

Protein Name

Solute carrier family 22 member 1

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.