Anti-TIGIT Monoclonal Antibody [7E5]

About this product

Boster Bio Anti-TIGIT Monoclonal Antibody [7E5] (Catalog # M01962) . Tested in ELISA, IHC-P, ICC, IF, Flow Cytometry applications. This antibody reacts with Human.

Specifications

Catalog number

M01962

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH) . TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses (1) . Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer (2) .

Synonyms

T-cell immunoreceptor with Ig and ITIM domains, VSIG9, VSTM3, WUCAM

Gene Name

TIGIT

UniProt

Q495A1

Host

Mouse

Reactivity

Human

Immunogen

TIGIT antibody was raised against the extracellular domain of human TIGIT.

Clonality

Monoclonal

Clone

Clone: Clone: 7E5

Tissue Specificity

Expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level) .

Applications

ELISA, IHC-P, ICC, IF, Flow Cytometry

Field of Research

Immunology

Purification

TIGIT Antibody is supplied as protein A purified IgG2b.

Concentration

1 mg/mL

Form

Liquid

Function

Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

Storage Conditions

TIGIT antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

26319 MW

Gene Name Synonym

T-cell immunoreceptor with Ig and ITIM domains

Subcellular Location

Cell membrane

Protein Name

T-cell immunoreceptor with Ig and ITIM domains

Isotype

IgG2b

Contents

TIGIT Antibody is supplied in PBS containing 0.02% sodium azide and 50% glycerol.