Anti-MEK-6 MAP2K6 Monoclonal Antibody

About this product

Boster Bio Anti-MEK-6 MAP2K6 Monoclonal Antibody catalog # M02011. Tested in WB, IF, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

M02011

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Dual specificity mitogen-activated protein kinase kinase 6; MAP kinase kinase 6; MAPKK 6;2.7.12.2; MAPK/ERK kinase 6; MEK 6; Stress-activated protein kinase kinase 3; SAPK kinase 3; SAPKK-3; SAPKK3; MAP2K6; MEK6, MKK6, PRKMK6, SKK3

Gene Name

MAP2K6

UniProt

P52564

Host

Mouse

Reactivity

Human, Mouse

Immunogen

Purified recombinant fragment of human MEK-6 expressed in E. Coli.

Clonality

Monoclonal

Clone

Clone: 3H12C8

Tissue Specificity

Isoform 2 is only expressed in skeletal muscle. Isoform 1 is expressed in skeletal muscle, heart, and in lesser extent in liver or pancreas.

Applications

WB, IF, Flow Cytometry, ELISA

Purification

Affinity purification

Concentration

1 mg/mL

Form

Liquid

Function

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG- dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

37492 MW

Gene Name Synonym

Dual specificity mitogen-activated protein kinase kinase 6

Subcellular Location

Nucleus

Protein Name

Dual specificity mitogen-activated protein kinase kinase 6

Isotype

IgG

Contents

Ascitic fluid containing 0.03% sodium azide.