Anti-MD-2 LY96 Monoclonal Antibody [9F1B1]

About this product

Boster Bio Anti-MD-2 LY96 Monoclonal Antibody [9F1B1] (Catalog # M02107) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

M02107

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) . TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.

Synonyms

MD2, MD-2, ly-96, ESOP-1

Gene Name

LY96

UniProt

Q9Y6Y9

Host

Mouse

Reactivity

Human, Mouse

Immunogen

Mouse monoclonal MD-2 antibody was raised against a recombinant protein corresponding to amino acids 2 to 160 of human MD-2.

Clonality

Monoclonal

Clone

Clone: Clone: 9F1B1

Applications

ELISA, WB, IHC-P, IF

Field of Research

Innate Immunity

Purification

MD-2 Monoclonal Antibody is Protein A purified.

Concentration

1 mg/mL

Form

Liquid

Function

Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869) . Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram- positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030) . Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581) . Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581) .

Storage Conditions

MD-2 monoclonal antibody can be stored at -20°C, stable for one year.

Observed Molecular Weight

18546 MW

Gene Name Synonym

Lymphocyte antigen 96

Subcellular Location

Secreted, extracellular space

Protein Name

Lymphocyte antigen 96

Isotype

IgG1

Contents

MD-2 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.