Anti-PDIA1 Antibody

About this product

Boster Bio Anti-PDIA1 Antibody (Catalog # M02335-1) . Tested in WB application (s) . This antibody reacts with Human.

Specifications

Catalog number

M02335-1-50ul

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity) . May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP.

Synonyms

Protein disulfide-isomerase, PDI, Cellular thyroid hormone-binding protein, Prolyl 4-hydroxylase subunit beta, p55, P4HB, ERBA2L, PDI, PDIA1, PO4DB

Gene Name

P4HB

UniProt

P07237

Host

Mouse

Reactivity

Human

Immunogen

This PDIA1 antibody is generated from a mouse immunized with a recombinant protein of human PDIA1.

Clonality

Monoclonal

Clone

Clone: 1530CT836.11.53

Applications

WB

Field of Research

Cancer, Metabolism, Signal Transduction

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

3214942621670307

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

57116 Da

Applications Notes

WB: 1:4000

Subcellular Location

Endoplasmic reticulum. Endoplasmic reticulum lumen. Melanosome. Cell membrane; Peripheral membrane protein. Note=Highly abundant. In some cell types, seems to be also secreted or associated with the plasma membrane, where it undergoes constant shedding and replacement from intracellular sources (Probable) . Localizes near CD4-enriched regions on lymphoid cell surfaces (PubMed:11181151) . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:10636893) Colocalizes with MTTP in the endoplasmic reticulum (PubMed:23475612) {ECO:0000269|PubMed:10636893, ECO:0000269|PubMed:11181151, ECO:0000269|PubMed:23475612, ECO:0000305}

Isotype

IgG1, k

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.