Anti-HINT1 Antibody

About this product

Boster Bio Anti-HINT1 Antibody (Catalog # M02557) . Tested in WB, Flow Cytometry, IHC-P, IF application (s) . This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

M02557-80ul

Size / count

80 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate) . Hydrolyzes lysyl-AMP (AMP-N-epsilon- (N-alpha-acetyl lysine methyl ester) ) generated by lysine tRNA ligase, as well as Met-AMP, His- AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon- (N-alpha-acetyl lysine methyl ester) ) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O- phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin- protein ligase complex.

Synonyms

Histidine triad nucleotide-binding protein 1, 3---, Adenosine 5'-monophosphoramidase, Protein kinase C inhibitor 1, Protein kinase C-interacting protein 1, PKCI-1, HINT1, HINT, PKCI1, PRKCNH1

Gene Name

HINT1

UniProt

P49773

Host

Mouse

Reactivity

Human, Mouse, Rat

Immunogen

This HINT1 antibody is generated from a mouse immunized with a recombinant protein of human HINT1.

Clonality

Monoclonal

Clone

Clone: 1500CT836.13.93

Tissue Specificity

Widely expressed.

Applications

WB, Flow Cytometry, IHC-P, IF

Field of Research

Cancer

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

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Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

13802 Da

Subcellular Location

Cytoplasm. Nucleus. Note=Interaction with CDK7 leads to a more nuclear localization.

Isotype

IgG1, k

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.