Anti-PRMT6 monoclonal Antibody

About this product

Boster Bio Anti-PRMT6 monoclonal Antibody catalog # M02924. Tested in WB, IHC, ICC applications. This antibody reacts with Human.

Specifications

Catalog number

M02924

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Protein arginine N-methyltransferase 6;2.1.1.319

Gene Name

PRMT6

UniProt

Q96LA8

Host

Mouse

Reactivity

Human

Immunogen

Recombinant full length Human PRMT6.

Clonality

Monoclonal

Tissue Specificity

Highly expressed in kidney and testis.

Applications

WB, IHC, ICC

Purification

The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910) . Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910) . Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a (PubMed:17898714, PubMed:18079182, PubMed:18077460) . H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3) (PubMed:17898714, PubMed:18077460) . Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53 (PubMed:19509293) . Repression of TP53 blocks cellular senescence (By similarity) . Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively) . Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity (PubMed:16600869) . Methylates HMGA1 (PubMed:16157300, PubMed:16159886) . Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC) (PubMed:17267505) . Methylates GPS2, protecting GPS2 from ubiquitination and degradation (By similarity) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

41938 MW

Gene Name Synonym

Protein arginine N-methyltransferase 6

Subcellular Location

Nucleus

Protein Name

Protein arginine N-methyltransferase 6

Contents

1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2